Correlations of mucin 5B gene polymorphisms and expression levels with the risk of onset of coal workers’ pneumoconiosis
Li Yang, Hao Deng, Hongyun Chen, Mali Wu, Jun Li, Tao Zhang · 2024
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Description
Li Yang and co-authors published a study in 2024 on a mucus gene and coal workers' lung scarring disease. The team compared healthy men, dust-exposed workers, and patients at two disease stages, over five hundred Han Chinese men in all. Three variants in the MUC5B gene were typed, and the gene's activity in blood cells was measured.
Two variants showed no link to disease. The third variant's forms appeared more often in patients, and those same forms came with lower gene activity. Patients' gene activity ran well below that of exposed and healthy men. A cutoff test flagged the measure as a sensitive early marker. The authors suggest screening dust workers by this gene.
Catalog record
| CREATOR | Li Yang, Hao Deng, Hongyun Chen, Mali Wu, Jun Li, Tao Zhang |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 21 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |