Bioinformatics-based discovery of biomarkers and immunoinflammatory infiltrates in hip fractures complicating deep vein thrombosis: A STROBE
Zhijiang Fu, Chao Song, Yongliang Mei, Daqian Zhou, Yang Zhou, Jingwen Chen, Fei Liu, Qing Shang, Zongchao Liu · 2024
Read Bioinformatics-based discovery of biomarkers and immunoinflammatory infiltrates in hip fractures complicating deep vein thrombosis: A STROBE by Zhijiang Fu, Chao Song, Yongliang Mei, Daqian Zhou, Yang Zhou, Jingwen Chen, Fei Liu, Qing Shang, Zongchao Liu (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11688061.txt.
Description
Zhijiang Fu and co-authors published a 2024 study mining gene data for markers of dangerous blood clots after hip fracture. Deep vein thrombosis is a common, sometimes deadly companion of hip fractures in middle-aged and older patients. Its molecular triggers are poorly understood. The team searched public expression datasets for genes that distinguish patients who develop clots.
They combined hip fracture and vein thrombosis datasets from a large open database. Analysis highlighted candidate biomarker genes and the signaling pathways they sit in. A second layer estimated which immune cells infiltrate the tissue, linking the markers to inflammation patterns. Such markers, if validated, could flag high-risk fracture patients for preventive treatment before a clot forms. The authors frame the work as hypothesis-building from data already collected. Its value depends on follow-up experiments, but it narrows a wide search to a short list.
Catalog record
| CREATOR | Zhijiang Fu, Chao Song, Yongliang Mei, Daqian Zhou, Yang Zhou, Jingwen Chen, Fei Liu, Qing Shang, Zongchao Liu |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 30 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |