Anaplerotic filling in heart failure: a review of mechanism and potential therapeutics
Karm A Alhasan, Melissa A King, Badal S B Pattar, Ian A Lewis, Gary D Lopaschuk, Steven C Greenway · 2024
Read Anaplerotic filling in heart failure: a review of mechanism and potential therapeutics by Karm A Alhasan, Melissa A King, Badal S B Pattar, Ian A Lewis, Gary D Lopaschuk, Steven C Greenway (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11687400.txt.
Description
Karm Alhasan and five co-authors review how the failing heart refills its energy cycle, and whether drugs could help, in a 2024 paper. Heart failure is a leading killer worldwide, and current drugs, though helpful, leave the cell’s energy shortage largely untouched. The heart burns fuel through a cycle whose parts leak away as waste products.
Refilling those lost parts is called anaplerosis, and it keeps energy flowing when demand is high. Failing hearts show clear changes in this refilling, which makes it a tempting drug target. The review gathers recent work on which refill routes rise or fall in failure, and which candidate compounds might restore them. Energy-first treatments could one day join today’s pressure and rhythm drugs.
Catalog record
| CREATOR | Karm A Alhasan, Melissa A King, Badal S B Pattar, Ian A Lewis, Gary D Lopaschuk, Steven C Greenway |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 62 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |