GDF15 antagonism limits severe heart failure and prevents cardiac cachexia
Minoru Takaoka, John A Tadross, Ali B A K Al-Hadithi, Xiaohui Zhao, Rocío Villena-Gutiérrez, Jasper Tromp, Shazia Absar, Marcus Au, James Harrison, Anthony P Coll, Stefan J Marciniak, Debra Rimmington, Eduardo Oliver, Borja Ibáñez, Adriaan A Voors, Stephen O’Rahilly, Ziad Mallat, Jane C Goodall · 2024
Read GDF15 antagonism limits severe heart failure and prevents cardiac cachexia by Minoru Takaoka, John A Tadross, Ali B A K Al-Hadithi, Xiaohui Zhao, Rocío Villena-Gutiérrez, Jasper Tromp, Shazia Absar, Marcus Au, James Harrison, Anthony P Coll, Stefan J Marciniak, Debra Rimmington, Eduardo Oliver, Borja Ibáñez, Adriaan A Voors, Stephen O’Rahilly, Ziad Mallat, Jane C Goodall (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11687397.txt.
Description
Minoru Takaoka and nineteen co-authors finger a stress hormone as the driver of wasting in severe heart failure. Their 2024 study uses mice whose stress-response machinery is broken in the blood-forming system. After irradiation and a marrow transplant, those mice developed a dilated, failing heart and severe weight loss, while normal mice were untouched.
The failing hearts poured out the protein GDF15, and blood levels rose with it. Blocking that protein's action prevented the wasting and slowed the heart failure's progress. The team also tied the protein to lean mass and protein intake in human heart failure patients. Their conclusion is a therapeutic suggestion. Cachexia in heart failure may not be a side effect to endure. It may be a hormone-driven process that can be interrupted, with gains in weight and heart function.
Catalog record
| CREATOR | Minoru Takaoka, John A Tadross, Ali B A K Al-Hadithi, Xiaohui Zhao, Rocío Villena-Gutiérrez, Jasper Tromp, Shazia Absar, Marcus Au, James Harrison, Anthony P Coll, Stefan J Marciniak, Debra Rimmington, Eduardo Oliver, Borja Ibáñez, Adriaan A Voors, Stephen O’Rahilly, Ziad Mallat, Jane C Goodall |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 52 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |