Stigmasterol mitigates estrogen-deficiency-induced osteoporosis through inhibition of phosphorylated p65 and MAPK signaling pathways
Qiangqiang Zhao, Xingling Chen, Bin Mai, Feihong Che, Zhen Zhang, Pan Kang, Chengyu Hou, Lu Lu, Liangliang Xu · 2024
Read Stigmasterol mitigates estrogen-deficiency-induced osteoporosis through inhibition of phosphorylated p65 and MAPK signaling pathways by Qiangqiang Zhao, Xingling Chen, Bin Mai, Feihong Che, Zhen Zhang, Pan Kang, Chengyu Hou, Lu Lu, Liangliang Xu (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11685749.txt.
Description
Qiangqiang Zhao and co-authors test a plant sterol against bone loss after the ovaries are removed in a 2024 study. Bone-eating cells drive the loss, and curbing them is a main line of care. The sterol, drawn from plants, had shown hints of slowing those cells, though the path was unclear.
In dish tests, the sterol cut the count and spread of bone-eating cells and blocked their grip rings. Key marks of the cells fell at both gene and protein levels. Two signal paths tied to the cells' birth were damped. In mice, scans and stains checked whether bone mass held up better under the sterol.
Catalog record
| CREATOR | Qiangqiang Zhao, Xingling Chen, Bin Mai, Feihong Che, Zhen Zhang, Pan Kang, Chengyu Hou, Lu Lu, Liangliang Xu |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 45 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |