Low-Intensity Blast Exposure Induces Multifaceted Long-Lasting Anxiety-Related Behaviors in Mice
Heather R. Siedhoff, Shanyan Chen, Ashley Balderrama, Dejun Jackson, Runting Li, Grace Y. Sun, Ralph G. DePalma, Jiankun Cui, Zezong Gu · 2024
Read Low-Intensity Blast Exposure Induces Multifaceted Long-Lasting Anxiety-Related Behaviors in Mice by Heather R. Siedhoff, Shanyan Chen, Ashley Balderrama, Dejun Jackson, Runting Li, Grace Y. Sun, Ralph G. DePalma, Jiankun Cui, Zezong Gu (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11685500.txt.
Description
Siedhoff and eight co-authors show low-intensity blast exposure causes lasting anxiety-related behaviors in mice, in a study from twenty twenty-four. Blast is a leading cause of mild brain injury in service members. Behavioral fallout can persist and erode quality of life. Male mice receive a single non-inertial blast in the Missouri Blast model.
Three months later, standard open-field tests show no anxiety difference. Social tests hint at reduced sociability without reaching significance. An advanced ladder test reveals early escape behavior before cues, an anxiety sign the field test misses. Effects are subtle, multifaceted, and long-lasting overall. The platform supports future work on domain-specific mechanisms.
Catalog record
| CREATOR | Heather R. Siedhoff, Shanyan Chen, Ashley Balderrama, Dejun Jackson, Runting Li, Grace Y. Sun, Ralph G. DePalma, Jiankun Cui, Zezong Gu |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 25 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |