Bifidobacterium longum JBLC-141 alleviates hypobaric hypoxia-induced intestinal barrier damage by attenuating inflammatory responses and oxidative stress
Xiang-Yang Li, Jin Shang, Xiao-Juan Wang, Hui-Ping Ma, Long-Fei Ren, Lei Zhang · 2024
Read Bifidobacterium longum JBLC-141 alleviates hypobaric hypoxia-induced intestinal barrier damage by attenuating inflammatory responses and oxidative stress by Xiang-Yang Li, Jin Shang, Xiao-Juan Wang, Hui-Ping Ma, Long-Fei Ren, Lei Zhang (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11685222.txt.
Description
Xiang-Yang Li and five co-authors published a 2024 rat study of a probiotic against gut damage from thin air. At high altitude, low pressure and low oxygen inflame the intestine, stir oxidative stress, and break its barrier. The team exposed rats to a simulated plateau and fed some a Bifidobacterium longum strain taken from healthy adults in a longevity region of China.
The probiotic switched on an antioxidant defense pathway in the gut, easing oxidative injury. It calmed inflammation and restored the proteins that seal the gut wall, cutting leakiness and repairing tissue damage. Gut microbe balance improved too, with helpful species up and harmful ones down. The authors present the strain as a candidate shield for people living or working at altitude.
Catalog record
| CREATOR | Xiang-Yang Li, Jin Shang, Xiao-Juan Wang, Hui-Ping Ma, Long-Fei Ren, Lei Zhang |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 39 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |