Leveraging single-cell and multi-omics approaches to identify MTOR-centered deubiquitination signatures in esophageal cancer therapy
Kang Tian, Ziang Yao, Da Pan · 2024
Read Leveraging single-cell and multi-omics approaches to identify MTOR-centered deubiquitination signatures in esophageal cancer therapy by Kang Tian, Ziang Yao, Da Pan (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11685190.txt.
Description
Kang Tian and co-authors built a gene signature to forecast outcomes in throat cancer in this 2024 study. The cancer is esophageal squamous cell carcinoma, a fast-growing type with poor survival. The team focused on genes that undo ubiquitin tags, the cell's system for marking proteins for removal.
They combined single-cell data, bulk gene data, and mutation records from public sets. A model based on 14 of these genes split patients into high and low risk groups. High-risk patients lived shorter lives and carried more gene changes. Lab and mouse tests singled out one gene, MTOR, as a drug target worth chasing. The signature may help doctors tailor care to each patient.
Catalog record
| CREATOR | Kang Tian, Ziang Yao, Da Pan |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 43 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |