Quantitative study on hepatic genotoxicity of neodymium and its molecular mechanisms based on Benchmark Dose method
Ning Wang · 2024
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Description
Ning Wang (2024) measured how the rare earth element neodymium damages DNA in mouse liver. Workers and communities near rare earth mining face growing exposure, and the element was already known to be genotoxic. Mice received neodymium nitrate by stomach tube for 28 days. The team measured the metal stored in liver tissue. They gauged DNA breaks with the comet assay and tracked damage markers and stress genes.
The metal built up in the liver. Treated mice showed more broken DNA strands in liver cells, plus higher levels of reactive oxygen and two damage markers. A whole defense pathway switched on: genes around the guardian protein p53 rose, including its sensors and brakes. Wang used benchmark dose methods to put numbers on the harm. The study links the damage to oxidative stress and the cell's alarm system, and argues exposure limits deserve closer study.
Catalog record
| CREATOR | Ning Wang |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 43 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |