Unveiling the Antimycobacterial Potential of Novel 4-Alkoxyquinolines: Insights into Selectivity, Mechanism of Action, and In Vivo Exposure
Fernanda · 2024
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Description
A large research team designed and tested a new family of compounds against the tuberculosis bacterium, in this 2024 study. The compounds, called 4-alkoxyquinolines, were built by simplifying a known structure and lengthening part of it. Tuberculosis still needs fresh drug candidates, above all ones that work on resistant strains.
The lead compound hit both normal and drug-resistant forms of the bacterium and aimed at a known energy-making target in the cell. It dissolved well and stayed stable in acid. In infected mouse immune cells it held the bacteria in check, and mice fed the compound absorbed it well. The authors say the simplified design opens a new path for this chemical family in TB drug work.
Catalog record
| CREATOR | Fernanda |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 73 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |