Miniature Mass Spectrometry for Point-of-Care Testing the GPIIb/IIIa Inhibitor Tirofiban during Perioperative Period of Percutaneous Coronary Intervention
Dongchen Zhou, Jiahui Wu, Qingcheng Wang, Yong Liu, Shiqi Wang, Weizong Zhang, Yunfeng Zhang, Huizhi Ding, Yunfei Shao, Haixing Wang, Qing Shen · 2024
Read Miniature Mass Spectrometry for Point-of-Care Testing the GPIIb/IIIa Inhibitor Tirofiban during Perioperative Period of Percutaneous Coronary Intervention by Dongchen Zhou, Jiahui Wu, Qingcheng Wang, Yong Liu, Shiqi Wang, Weizong Zhang, Yunfeng Zhang, Huizhi Ding, Yunfei Shao, Haixing Wang, Qing Shen (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11683618.txt.
Description
Dongchen Zhou and colleagues built a portable mass spectrometer test for the drug tirofiban. Their 2024 paper serves point-of-care testing during heart treatment. Tirofiban blocks platelet receptors and needs precise dosing. Too much or too little can harm the patient. Fast blood level checks at the bedside would guide that dosing.
The device pairs paper spray ionization with a small ion trap. Blood samples can be run on site with instant analysis. The drug showed a stable parent ion peak in testing. Fragment patterns confirmed identity under collision steps. Settings were tuned to strengthen the ion signal. Validation checked the method's limits for clinical use. The system aims to bring lab-grade drug checks to the ward.
Catalog record
| CREATOR | Dongchen Zhou, Jiahui Wu, Qingcheng Wang, Yong Liu, Shiqi Wang, Weizong Zhang, Yunfeng Zhang, Huizhi Ding, Yunfei Shao, Haixing Wang, Qing Shen |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 25 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |