Asymmetrical Evolution of Promoter Methylation of Mammalian Genes after Duplication
Mercedes de la Fuente, Isabel Mendizabal, Mira V Han, Soojin V Yi, David Alvarez-Ponce, Flavia Mascagni · 2024
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Description
Mercedes de la Fuente and co-authors study how gene copies diverge after a gene is duplicated, in a 2024 paper. Duplication is a main source of new genes. Right after it happens, two copies do the same job, which can flood the cell with product. New duplicates are often quiet, in part because chemical marks silence them.
The team compared those marks in ten human and sixteen mouse tissues. They set single genes against duplicates and matched genes across the two species. In mice, duplicates carried more marks than single genes on average. The pattern in humans differed. The work asks whether marks fall on one copy or both, and how that choice shapes the fate of new genes.
Catalog record
| CREATOR | Mercedes de la Fuente, Isabel Mendizabal, Mira V Han, Soojin V Yi, David Alvarez-Ponce, Flavia Mascagni |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 43 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |