In vitro elimination of antimicrobials during ADVanced Organ Support hemodialysis
Christina König, Otto Frey, Susanne Himmelein, Lisa Mulack, Alexander Brinkmann, Aritz Perez Ruiz de Garibay, Tobias Bingold · 2024
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Description
Christina König and six co-authors measure how much of eight antimicrobial drugs a new albumin-based dialysis system pulls out of blood. Their laboratory study was published in twenty twenty-four. The machine's albumin fluid strips protein-bound toxins, and drug loss was uncharted.
Pig blood circulated through the system while drugs were infused. All eight were removed. Low protein-bound drugs cleared at a few liters per hour at the test flow. Doubling the blood flow changed clearance further, detailed in the full report. Dosing in patients on this machine cannot copy ordinary dialysis rules; these numbers are the starting point for adjusted regimens.
Catalog record
| CREATOR | Christina König, Otto Frey, Susanne Himmelein, Lisa Mulack, Alexander Brinkmann, Aritz Perez Ruiz de Garibay, Tobias Bingold |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 23 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |