Experimental prescription, rising resistance: the alarming misuse of ceftazidime-avibactam in healthcare systems
Mojtaba Akbari, Christian G Giske, Hamid Solgi · 2024
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Description
Mojtaba Akbari, Christian Giske, and Hamid Solgi write a letter warning against careless use of a last-line antibiotic pair, ceftazidime-avibactam. Carbapenem-resistant bacteria are spreading in hospitals worldwide, leaving few working drugs. The new pair is a first choice against some resistant strains, but not all.
The drug pair fails against bacteria carrying metallo-beta-lactamase enzymes. In Iran, the writers note, the dominant resistance genes include exactly those types, often paired in one Klebsiella strain. Guessing with this drug as solo therapy there invites failure and breeds more resistance. They cite a first reported failure in a ninety-one-year-old patient. Their plea: test first, then prescribe.
Catalog record
| CREATOR | Mojtaba Akbari, Christian G Giske, Hamid Solgi |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 4 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |