Clonal Hematopoiesis in Chronic Thromboembolic Pulmonary Hypertension
Mizuki Momoi, Yoshinori Katsumata, Hiroyoshi Kunimoto, Takumi Inami, Fuyuki Miya, Atsushi Anzai, Shinichi Goto, Ayaka Miura, Yoshiki Shinya, Takahiro Hiraide, Kohsuke Shirakawa, Jin Endo, Keiichi Fukuda, Masaki Ieda, Kenjiro Kosaki, Hideaki Nakajima, Masaharu Kataoka · 2024
Read Clonal Hematopoiesis in Chronic Thromboembolic Pulmonary Hypertension by Mizuki Momoi, Yoshinori Katsumata, Hiroyoshi Kunimoto, Takumi Inami, Fuyuki Miya, Atsushi Anzai, Shinichi Goto, Ayaka Miura, Yoshiki Shinya, Takahiro Hiraide, Kohsuke Shirakawa, Jin Endo, Keiichi Fukuda, Masaki Ieda, Kenjiro Kosaki, Hideaki Nakajima, Masaharu Kataoka (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11681603.txt.
Description
Mizuki Momoi and co-authors asked whether age related blood stem cell mutations worsen a lung artery disease caused by old clots, in work published in 2024. Gene sequencing covered more than two hundred patients. About one in five carried such mutations, and nearly half of patients in their eighties did.
Carriers had higher heart strain markers, needed home oxygen more often, and walked shorter distances after treatment. Fresh clots and repeat artery procedures were also more common in carriers. Gene activity and blood tests pointed to neutrophil traps as the link. The authors suggest the mutations push a clot friendly state that blunts treatment gains.
Catalog record
| CREATOR | Mizuki Momoi, Yoshinori Katsumata, Hiroyoshi Kunimoto, Takumi Inami, Fuyuki Miya, Atsushi Anzai, Shinichi Goto, Ayaka Miura, Yoshiki Shinya, Takahiro Hiraide, Kohsuke Shirakawa, Jin Endo, Keiichi Fukuda, Masaki Ieda, Kenjiro Kosaki, Hideaki Nakajima, Masaharu Kataoka |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 46 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |