Urinary Dickkopf‐3 as a Potential Marker for Estimated Glomerular Filtration Rate Decline in Patients With Heart Failure
Dennis Pieper, Anja Sandek, Ann‐Kathrin Schäfer, Hassan Dihazi, Gry Helene Dihazi, Andreas Leha, Michael Zeisberg, Stephan Lüders, Michael Koziolek, Manuel Wallbach · 2024
Read Urinary Dickkopf‐3 as a Potential Marker for Estimated Glomerular Filtration Rate Decline in Patients With Heart Failure by Dennis Pieper, Anja Sandek, Ann‐Kathrin Schäfer, Hassan Dihazi, Gry Helene Dihazi, Andreas Leha, Michael Zeisberg, Stephan Lüders, Michael Koziolek, Manuel Wallbach (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11681579.txt.
Description
Dennis Pieper, Anja Sandek, Ann-Kathrin Schäfer, and a team of co-authors test whether a protein in urine can warn of failing kidneys in people with heart failure. The two organs fail together so often that doctors speak of a cardiorenal syndrome, and catching kidney decline early opens a window to act.
They measured the protein, called DKK3, in several hundred heart failure patients and a small control group, then tracked kidney function for up to five years. Levels ran much higher in the patients, and those above a cutoff lost kidney function notably faster over the next year. The signal held even in patients whose kidneys were still healthy. The authors call the marker promising for early warning.
Catalog record
| CREATOR | Dennis Pieper, Anja Sandek, Ann‐Kathrin Schäfer, Hassan Dihazi, Gry Helene Dihazi, Andreas Leha, Michael Zeisberg, Stephan Lüders, Michael Koziolek, Manuel Wallbach |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 46 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |