Coronary Microvascular Dysfunction Is Associated With Augmented Lysosomal Signaling in Hypercholesterolemic Mice
Yun‐Ting Wang, Alexandra K Moura, Rui Zuo, Wei Zhou, Zhengchao Wang, Kiana Roudbari, Jenny Z Hu, Pin‐Lan Li, Yang Zhang, Xiang Li · 2024
Read Coronary Microvascular Dysfunction Is Associated With Augmented Lysosomal Signaling in Hypercholesterolemic Mice by Yun‐Ting Wang, Alexandra K Moura, Rui Zuo, Wei Zhou, Zhengchao Wang, Kiana Roudbari, Jenny Z Hu, Pin‐Lan Li, Yang Zhang, Xiang Li (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11681558.txt.
Description
Yun-Ting Wang and nine co-authors study tiny heart vessels that fail early under high cholesterol, in a 2024 mouse study. Before any heart damage shows, the small vessels that feed the heart can lose their flow reserve. The team fed mice a rich diet for eight weeks and tracked heart flow with sound scans, then probed the vessel lining in tissue and in lab cells.
The diet cut flow reserve while leaving heart shape and pumping untouched. Vessel linings fired up a cleanup system inside cells, run by a switch called TFEB, and swelling cells crept into the heart wall. A cholesterol-lowering drug eased all of it. In lab cells, blocking the cleanup made a harsh cholesterol by-product worse, so the authors read the cleanup as a shield.
Catalog record
| CREATOR | Yun‐Ting Wang, Alexandra K Moura, Rui Zuo, Wei Zhou, Zhengchao Wang, Kiana Roudbari, Jenny Z Hu, Pin‐Lan Li, Yang Zhang, Xiang Li |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 70 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |