Initial pig developmental stage influences intestinal organoid growth but not cellular composition
Camille Duchesne, Gwénaëlle Randuineau, Laurence Le Normand, Véronique Romé, Samia Laraqui, Alexis Pierre Arnaud, Gaëlle Boudry · 2024
Read Initial pig developmental stage influences intestinal organoid growth but not cellular composition by Camille Duchesne, Gwénaëlle Randuineau, Laurence Le Normand, Véronique Romé, Samia Laraqui, Alexis Pierre Arnaud, Gaëlle Boudry (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11680479.txt.
Description
Pig gut organoids could cut the need for live animal tests, and a 2024 study by Camille Duchesne and co-authors asks how the donor pig's age shapes them. The team grew organoids from gut stem cells and compared their growth, shape, and cell makeup across ages.
Stem cells came from the jejunum and colon of pigs aged one day to six months, and the organoids were passed three times. Colon cells made more and larger organoids than jejunum cells. Age mattered for growth and shape: cells from young piglets gave a higher share of organoids over round spheroids. Yet age did not change the cell makeup of the organoids. The study helps labs pick donor ages for this model.
Catalog record
| CREATOR | Camille Duchesne, Gwénaëlle Randuineau, Laurence Le Normand, Véronique Romé, Samia Laraqui, Alexis Pierre Arnaud, Gaëlle Boudry |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 36 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |