Heterogeneous Ribonucleoprotein K Is a Host Regulatory Factor of Chikungunya Virus Replication in Astrocytes
Lisa Pieterse, Maranda McDonald, Rachy Abraham, Diane E. Griffin · 2024
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Description
Lisa Pieterse and three co-authors study how chikungunya virus copies itself inside brain cells in a 2024 paper. The virus spreads by mosquito bite and is best known for joint pain, but it can also harm the nervous system. Astrocytes, the brain's support cells, are its main target there.
The team focused on a host protein called hnRNP K, which binds RNA. They found the spot where the protein grips the viral RNA and bred a mutant virus that breaks that grip. The mutant grew poorly in both nerve and astrocyte cells. In astrocytes, it also failed to switch on a late step in making viral proteins.
Catalog record
| CREATOR | Lisa Pieterse, Maranda McDonald, Rachy Abraham, Diane E. Griffin |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 46 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |