Epigenetic Drift Is Involved in the Efficacy of HBV Vaccination
Francesca Ferraresi, Simona Anticoli, Stefano Salvioli, Chiara Pirazzini, Luciano Calzari, Davide Gentilini, Christian Albano, Reparata Rosa Di Prinzio, Salvatore Zaffina, Rita Carsetti, Paolo Garagnani, Anna Ruggieri, Katarzyna Malgorzata Kwiatkowska, Amine A Kamen, Wangxue Chen, Xuguang Li · 2024
Read Epigenetic Drift Is Involved in the Efficacy of HBV Vaccination by Francesca Ferraresi, Simona Anticoli, Stefano Salvioli, Chiara Pirazzini, Luciano Calzari, Davide Gentilini, Christian Albano, Reparata Rosa Di Prinzio, Salvatore Zaffina, Rita Carsetti, Paolo Garagnani, Anna Ruggieri, Katarzyna Malgorzata Kwiatkowska, Amine A Kamen, Wangxue Chen, Xuguang Li (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11680278.txt.
Description
The authors study why some people fail to build protection after a hepatitis B vaccine, focusing on slow drift in gene-control marks. Their 2024 study looks at rare methylation changes in B cells, the immune cells that make antibodies. Up to ten percent of vaccinated people stay unprotected.
Samples came from forty-one responders and thirty non-responders, aged twenty-two to sixty-two. Non-responders carried more of the rare marks, mostly of the added-methyl kind. Certain chromosomes and immune-linked genes held clusters of them. Mark load also tracked with aging clocks and with a disorder score in men. The authors read failed response as partly an aging drift in gene control. They note the drift links may not drive the weak immunity itself.
Catalog record
| CREATOR | Francesca Ferraresi, Simona Anticoli, Stefano Salvioli, Chiara Pirazzini, Luciano Calzari, Davide Gentilini, Christian Albano, Reparata Rosa Di Prinzio, Salvatore Zaffina, Rita Carsetti, Paolo Garagnani, Anna Ruggieri, Katarzyna Malgorzata Kwiatkowska, Amine A Kamen, Wangxue Chen, Xuguang Li |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 40 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |