Genome Analysis of Anti-Phage Defense Systems and Defense Islands in Stenotrophomonas maltophilia: Preservation and Variability
Ghadeer Jdeed, Vera V. Morozova, Nina V. Tikunova · 2024
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Description
Ghadeer Jdeed, Vera Morozova, and Nina Tikunova catalogued in 2024 the weapons one troublesome bacterium uses against the viruses that infect bacteria. The species resists many antibiotics, which makes virus-based therapy attractive. But its own anti-virus defenses could blunt such treatment. Genome analysis across strains found 72 defense systems and subsystems, varying widely between strains.
Only seven systems appeared in more than a fifth of genomes, and their proteins often differed. Defenses clustered into 27 islands, with four islands holding most instances. Mobile elements nearby suggest the systems hop between strains. No tidy pattern linked defenses to family tree or isolation site. The map helps therapy designers pick viruses that can slip past each strain's particular arsenal.
Catalog record
| CREATOR | Ghadeer Jdeed, Vera V. Morozova, Nina V. Tikunova |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 24 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |