Study of Cytotoxicity of Spiro-Fused [3-Azabicyclo[3.1.0]hexane]oxindoles and Cyclopropa[a]pyrrolizidine-oxindoles Against Tumor Cell Lines †
Anton A. Kornev, Stanislav V. Shmakov, Alexander I. Ponyaev, Alexander V. Stepakov, Vitali M. Boitsov · 2024
Read Study of Cytotoxicity of Spiro-Fused [3-Azabicyclo[3.1.0]hexane]oxindoles and Cyclopropa[a]pyrrolizidine-oxindoles Against Tumor Cell Lines † by Anton A. Kornev, Stanislav V. Shmakov, Alexander I. Ponyaev, Alexander V. Stepakov, Vitali M. Boitsov (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11680018.txt.
Description
Anton Kornev and four co-authors synthesized in 2024 two families of spiro-shaped molecules and tested them against tumor cell lines. The compounds were screened on leukemia, cervical, melanoma and breast cancer cells, plus a mouse colon line. Four of them slowed growth at low doses across several lines. Microscopy and flow methods then probed how the cells were harmed.
Treated cells piled up in early and dying phases of the cell cycle. Their inner actin scaffolding fell apart, with stress fibers vanishing and surface fingers shrinking. In a scratch test, melanoma cells lost their ability to crawl into the gap. The authors say the pattern supports real antitumor action, not mere poisoning. They plan to push the chemistry further to raise potency and cut risk. The work sits at the drug-discovery starting line.
Catalog record
| CREATOR | Anton A. Kornev, Stanislav V. Shmakov, Alexander I. Ponyaev, Alexander V. Stepakov, Vitali M. Boitsov |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 28 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |