Integrating Single-Cell RNA-Seq and ATAC-Seq Analysis Reveals Uterine Cell Heterogeneity and Regulatory Networks Linked to Pimpled Eggs in Chickens
Wenqiang Li, Xueying Ma, Xiaomin Li, Xuguang Zhang, Yifei Sun, Chao Ning, Qin Zhang, Dan Wang, Hui Tang, George P Chrousos, Dimitrios Vlachakis · 2024
Read Integrating Single-Cell RNA-Seq and ATAC-Seq Analysis Reveals Uterine Cell Heterogeneity and Regulatory Networks Linked to Pimpled Eggs in Chickens by Wenqiang Li, Xueying Ma, Xiaomin Li, Xuguang Zhang, Yifei Sun, Chao Ning, Qin Zhang, Dan Wang, Hui Tang, George P Chrousos, Dimitrios Vlachakis (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11679886.txt.
Description
Wenqiang Li and co-authors map the cells of the chicken uterus to explain pimpled eggs, in a 2024 study. Such eggs carry rough, defective shells that hurt hatching and shipping. The uterus is where the shell forms.
Single cell gene reads and chromatin maps resolved eleven cell types and their marker genes. Fibroblasts ran the busiest talk network with other cells. Hens laying pimpled eggs showed swollen immune signaling, a disturbed daily rhythm, and shifts in ion transport genes. A handful of switch genes sit upstream of the trouble, while faded ion pumps act downstream. A rare ion handling cell type also surfaced from the joint maps.
Catalog record
| CREATOR | Wenqiang Li, Xueying Ma, Xiaomin Li, Xuguang Zhang, Yifei Sun, Chao Ning, Qin Zhang, Dan Wang, Hui Tang, George P Chrousos, Dimitrios Vlachakis |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 51 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |