The Impact of HIV on B Cell Compartment and Its Implications for COVID-19 Vaccinations in People with HIV
Lixing Wang, Branka Vulesevic, MariaLuisa Vigano, Alia As’sadiq, Kristina Kang, Cristina Fernandez, Suzanne Samarani, Aslam H Anis, Ali Ahmad, Cecilia T Costiniuk, Federico De Marco · 2024
Read The Impact of HIV on B Cell Compartment and Its Implications for COVID-19 Vaccinations in People with HIV by Lixing Wang, Branka Vulesevic, MariaLuisa Vigano, Alia As’sadiq, Kristina Kang, Cristina Fernandez, Suzanne Samarani, Aslam H Anis, Ali Ahmad, Cecilia T Costiniuk, Federico De Marco (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11679862.txt.
Description
Lixing Wang and co-authors review how HIV affects antibody making cells in a 2024 paper. These B cells build the antibodies that vaccines aim to train. HIV keeps them overactive yet less effective at the same time. The review asks what that means for COVID-19 vaccination in people with HIV.
Infection swells some B cell groups and shrinks the resting memory pool. Helper T cells that guide antibody growth also falter. Treatment that suppresses the virus repairs much of the damage, but not all of it. People whose immune systems recover poorly answer vaccines weakly. Leftover inflammation and early aging of immune cells add to the problem. The authors argue for vaccine plans tailored to this group.
Catalog record
| CREATOR | Lixing Wang, Branka Vulesevic, MariaLuisa Vigano, Alia As’sadiq, Kristina Kang, Cristina Fernandez, Suzanne Samarani, Aslam H Anis, Ali Ahmad, Cecilia T Costiniuk, Federico De Marco |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 73 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |