Metabolic Alterations of Short-Chain Organic Acids in the Elderly Link Antibiotic Exposure with the Risk for Depression
Shujing Sun, Li Kong, Fangting Hu, Sheng Wang, Menglong Geng, Hongjuan Cao, Xingyong Tao, Fangbiao Tao, Kaiyong Liu, Michael Lalk · 2024
Read Metabolic Alterations of Short-Chain Organic Acids in the Elderly Link Antibiotic Exposure with the Risk for Depression by Shujing Sun, Li Kong, Fangting Hu, Sheng Wang, Menglong Geng, Hongjuan Cao, Xingyong Tao, Fangbiao Tao, Kaiyong Liu, Michael Lalk (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11679812.txt.
Description
Antibiotics taken late in life have been tied to depression in older adults, and small acids from gut microbes may carry that link. Shujing Sun and co-authors traced the chain in this 2024 study. Their earlier work in Chinese community elders found the antibiotic-depression tie. This study measured short-chain organic acids in the blood as possible middlemen.
Urine tests gauged exposure to several antibiotics, including farm-use kinds. Depression symptoms were scored on a thirty-item geriatric scale. Some antibiotics tracked with fewer of certain acids, and one acid's level moved opposite to symptom scores. A fat-burning acid moved the other way. Gut chemistry may be one route from pills to mood.
Catalog record
| CREATOR | Shujing Sun, Li Kong, Fangting Hu, Sheng Wang, Menglong Geng, Hongjuan Cao, Xingyong Tao, Fangbiao Tao, Kaiyong Liu, Michael Lalk |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 38 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |