Comparative Evaluation of Mathematical Model and In Vivo Study of Calcium Phosphate Bone Grafts
Mikhail A Shlykov, Polina V Smirnova, Anatoliy S Senotov, Anastasia Yu Teterina, Vladislav V Minaychev, Igor V Smirnov, Roman A Novikov, Ekaterina I Marchenko, Pavel S Salynkin, Vladimir S Komlev, Roman S Fadeev, Irina S Fadeeva, Pankaj Vadgama · 2024
Read Comparative Evaluation of Mathematical Model and In Vivo Study of Calcium Phosphate Bone Grafts by Mikhail A Shlykov, Polina V Smirnova, Anatoliy S Senotov, Anastasia Yu Teterina, Vladislav V Minaychev, Igor V Smirnov, Roman A Novikov, Ekaterina I Marchenko, Pavel S Salynkin, Vladimir S Komlev, Roman S Fadeev, Irina S Fadeeva, Pankaj Vadgama (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11679695.txt.
Description
Mikhail Shlykov and co-authors test a math model of bone graft behavior against living tissue in a 2024 study. A graft's surface changes constantly after placement, and that surface governs how the body accepts it. Predicting the changes would let labs screen materials without animal trials.
The team built a semi-empirical model from chemical kinetics for a calcium phosphate graft material. It matched surface changes seen in a lab bioreactor and in grafts placed under rat skin. The lab setup, using a flow-through bioreactor with serum-rich medium, reproduced the same surface chemistry as the body. The authors argue such lab systems can stand in for animal models, guided by the math, in a chip-like testing platform.
Catalog record
| CREATOR | Mikhail A Shlykov, Polina V Smirnova, Anatoliy S Senotov, Anastasia Yu Teterina, Vladislav V Minaychev, Igor V Smirnov, Roman A Novikov, Ekaterina I Marchenko, Pavel S Salynkin, Vladimir S Komlev, Roman S Fadeev, Irina S Fadeeva, Pankaj Vadgama |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 62 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |