Repair of Retrorsine-Induced DNA Damage in Rat Livers: Insights Gained from Transcriptomic and Proteomic Studies
Yun Long, Yiwei Wang, Zijing Song, Xin He, Yisheng He, Ge Lin · 2024
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Description
Yun Long and co-authors study, in a 2024 paper, how rat livers repair DNA damage caused by a plant toxin. Such toxins, found worldwide in plants, are switched on in the liver and bind to DNA. Those bindings can drive mutations and liver tumors.
Rats received a human-relevant dose of the toxin retrorsine daily for 28 days. Some were examined right after, others after a long recovery gap. Gene and protein profiling showed two repair systems answering the damage: one that swaps in an undamaged template, and one that rejoins broken ends directly. Learning how the liver clears these adducts clarifies the true risk window after exposure.
Catalog record
| CREATOR | Yun Long, Yiwei Wang, Zijing Song, Xin He, Yisheng He, Ge Lin |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 38 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |