Targeting the Calcium-Sensing Receptor in Chemically Induced Medium-Grade Colitis in Female BALB/C Mice
Karina Piatek, Valeriya Gushchina, Ava Kleinwächter, Nadja Kupper, Ildiko Mesteri, Taha Elajnaf, Luca Iamartino, Martina Salzmann, Christian Müller, Teresa Manhardt, Andrea Vlasaty, Enikö Kallay, Martin Schepelmann · 2024
Read Targeting the Calcium-Sensing Receptor in Chemically Induced Medium-Grade Colitis in Female BALB/C Mice by Karina Piatek, Valeriya Gushchina, Ava Kleinwächter, Nadja Kupper, Ildiko Mesteri, Taha Elajnaf, Luca Iamartino, Martina Salzmann, Christian Müller, Teresa Manhardt, Andrea Vlasaty, Enikö Kallay, Martin Schepelmann (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11679268.txt.
Description
Karina Piatek and eleven co-authors test blocking a calcium sensor to prevent gut inflammation in mice in a 2024 paper. The sensor sits on many cells and was proposed as a drug target for inflammatory bowel disease. Earlier, blocking it mildly eased very severe mouse colitis, leaving open whether severity had masked a real benefit.
Female mice received the blocker or a dummy treatment before a chemical triggered medium grade colitis. Symptom scores did not improve, but treated colons were significantly longer and had less ulceration. Two inflammation related genes quieted in different colon regions, and lymph node cell growth fell. The authors read the mixed picture as partial protection worth further study.
Catalog record
| CREATOR | Karina Piatek, Valeriya Gushchina, Ava Kleinwächter, Nadja Kupper, Ildiko Mesteri, Taha Elajnaf, Luca Iamartino, Martina Salzmann, Christian Müller, Teresa Manhardt, Andrea Vlasaty, Enikö Kallay, Martin Schepelmann |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 32 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |