Iodine Deficiency Exacerbates Thyroidal and Neurological Effects of Developmental Perchlorate Exposure in the Neonatal and Adult Rat
Mary E. Gilbert, MaryAnn G. Hawks, Kiersten S. Bell, Wendy Oshiro, Carmen Wood, Barbara Jane George, Ryne Thomas, Jermaine Ford · 2024
Read Iodine Deficiency Exacerbates Thyroidal and Neurological Effects of Developmental Perchlorate Exposure in the Neonatal and Adult Rat by Mary E. Gilbert, MaryAnn G. Hawks, Kiersten S. Bell, Wendy Oshiro, Carmen Wood, Barbara Jane George, Ryne Thomas, Jermaine Ford (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11679215.txt.
Description
Mary Gilbert and seven co-authors study how two risks to the thyroid combine in young rats. Perchlorate, a pollutant, blocks iodine uptake; iodine itself is needed to make thyroid hormones that guide brain growth. The team exposed pregnant rats to perchlorate in drinking water, with either a normal or a low-iodine diet. Each risk alone lowered hormone levels in mothers but not in pups.
Together, the two risks lowered pup hormones and changed gene activity in the thyroid and brain. A key class of brain cells fell in number. As adults, offspring showed changes in startle and fear learning. The paper warns that single-risk tests can miss harm that pairs of risks cause.
Catalog record
| CREATOR | Mary E. Gilbert, MaryAnn G. Hawks, Kiersten S. Bell, Wendy Oshiro, Carmen Wood, Barbara Jane George, Ryne Thomas, Jermaine Ford |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 56 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |