Disentangling the Relationship Between Urinary Metal Exposure and Osteoporosis Risk Across a Broad Population: A Comprehensive Supervised and Unsupervised Analysis
Jianing Liu, Kai Wang · 2024
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Description
Metal exposure is widespread, but its link to osteoporosis in the general population is thinly documented. Jianing Liu and Kai Wang mined the United States NHANES survey from 1999 to 2020, covering 15,923 participants with urine measures of nine metals. Bone status came from dual-energy X-ray scans. They combined weighted quantile sum regression with clustering to weigh each metal's role and to split people into high and low exposure groups.
Cadmium stood out as a clear risk factor, with an odds ratio of 1.19 and two thirds of the mixture weight. Lead mattered most for 30 to 49 year olds and Mexican American participants, and antimony for Black participants. The high-exposure cluster had 1.74 times the osteoporosis odds and higher cumulative mortality. The authors conclude urinary metals track both osteoporosis risk and prognosis.
Catalog record
| CREATOR | Jianing Liu, Kai Wang |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 55 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |