The Effect of Milk-Derived Extracellular Vesicles on Intestinal Epithelial Cell Proliferation
Shimon Reif, Liron Birimberg-Schwartz, Myriam Grunewald, Deborah Duran, Naama Sebbag-Sznajder, Tirtsa Toledano, Mirit Musseri, Regina Golan-Gerstl, Carlos CABAÑAS · 2024
Read The Effect of Milk-Derived Extracellular Vesicles on Intestinal Epithelial Cell Proliferation by Shimon Reif, Liron Birimberg-Schwartz, Myriam Grunewald, Deborah Duran, Naama Sebbag-Sznajder, Tirtsa Toledano, Mirit Musseri, Regina Golan-Gerstl, Carlos CABAÑAS (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11678886.txt.
Description
Shimon Reif and co-authors study, in twenty twenty-four, whether tiny vesicles from milk can help heal the gut lining. Inflammatory bowel disease is a chronic, relapsing gut disorder that breaks the gut barrier. Even with modern biologic drugs, lasting remission is hard for many patients. Milk-derived vesicles are small packets shed by cells, now eyed as a therapy. The team isolated them and tested their effects on gut lining cells. In a mouse colitis model, the vesicles eased disease signs.
In colon tissue, a key Wnt pathway protein, beta-catenin, rose, which hints at lining repair. In patient-derived colon organoids, lab-grown mini guts, the vesicles entered cells and raised growth markers. In colon cancer cells, they did the reverse, lowering those proteins and slowing growth.
Catalog record
| CREATOR | Shimon Reif, Liron Birimberg-Schwartz, Myriam Grunewald, Deborah Duran, Naama Sebbag-Sznajder, Tirtsa Toledano, Mirit Musseri, Regina Golan-Gerstl, Carlos CABAÑAS |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 30 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |