Unlocking the Stratum Corneum Barrier to Skin Penetration for the Transdermal Delivery of Cyclovirobuxine D
Yun-Hao Ren, Feng-Yuan Song, Jing-Yu Zhao, Bing-Wen Liang, Li-Hua Peng, Natasa Skalko-Basnet, Rita Muzzalupo · 2024
Read Unlocking the Stratum Corneum Barrier to Skin Penetration for the Transdermal Delivery of Cyclovirobuxine D by Yun-Hao Ren, Feng-Yuan Song, Jing-Yu Zhao, Bing-Wen Liang, Li-Hua Peng, Natasa Skalko-Basnet, Rita Muzzalupo (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11678883.txt.
Description
Yun-Hao Ren and co-authors test ways to push a heart drug through skin in a 2024 study. The drug, cyclovirobuxine D from a medicinal plant, helps rhythm, blood pressure, and nerve protection, but it dissolves poorly. Oral and injected forms thus reach the body weakly and cause notable side effects, which makes skin delivery attractive if the outer skin barrier can be crossed.
Chemical enhancers and tiny lipid vesicles called niosomes were tested and tuned. One enhancer raised skin penetration more than four fold, the vesicles alone about one and a half fold. Putting both drug and enhancer inside the vesicles lifted penetration more than eight fold over the plain solvent form.
Catalog record
| CREATOR | Yun-Hao Ren, Feng-Yuan Song, Jing-Yu Zhao, Bing-Wen Liang, Li-Hua Peng, Natasa Skalko-Basnet, Rita Muzzalupo |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 55 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |