Transcription Factors ClrB and XlnR and Their Effect on the Transcription of Cellulase Genes in the Filamentous Fungus Penicillium verruculosum
Andrey Chulkin, Valeriy Kislitsin, Igor Sinelnikov, Arkady Sinitsyn, Ivan Zorov, Pavel Volkov, Aleksandra Rozhkova · 2024
Read Transcription Factors ClrB and XlnR and Their Effect on the Transcription of Cellulase Genes in the Filamentous Fungus Penicillium verruculosum by Andrey Chulkin, Valeriy Kislitsin, Igor Sinelnikov, Arkady Sinitsyn, Ivan Zorov, Pavel Volkov, Aleksandra Rozhkova (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11678864.txt.
Description
Andrey Chulkin and six co-authors sort out which switches turn on fiber-digesting enzymes in an industrial fungus. Their 2024 paper studies a mold prized for secreting cellulases used in biorefineries. Two regulator proteins are in question. Working with gene knockouts and forced expression, the team tracked three key enzyme genes under different sugar signals.
One regulator proved strictly in charge: it drove all three enzyme genes when the fungus fed on xylose or its paired form, though not on cellobiose. The second regulator, the master switch in several related molds, played no such lead role here and seems to do a different job in this genus. Forcing the first regulator on raised two enzyme activities in the production strain, several-fold in one case. The authors point to that strain as a better base for turning plant waste into useful products.
Catalog record
| CREATOR | Andrey Chulkin, Valeriy Kislitsin, Igor Sinelnikov, Arkady Sinitsyn, Ivan Zorov, Pavel Volkov, Aleksandra Rozhkova |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 40 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |