Caralluma fimbriata Extract Improves Vascular Dysfunction in Obese Mice Fed a High-Fat Diet
Venkata Bala Sai Chaitanya Thunuguntla, Laura Kate Gadanec, Catherine McGrath, Joanne Louise Griggs, Puspha Sinnayah, Vasso Apostolopoulos, Anthony Zulli, Michael L. Mathai · 2024
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Description
Venkata Thunuguntla and seven co-authors test a cactus extract on the blood vessels of obese mice in a 2024 study. Obesity stiffens arteries and dulls their ability to relax, seeding heart disease. The extract, from Caralluma fimbriata, is known for curbing appetite, but its vessel effects were uncharted.
Eighty mice grew fat on sixteen weeks of rich food, then received the extract, a prescription diet drug, both, or neither. The team weighed fat, then tested artery rings in baths for their relaxing response and stained them for stress signals. The extract improved the vessels' relaxation and shifted the stress markers, standing beside the drug as a gentler candidate worth clinical attention.
Catalog record
| CREATOR | Venkata Bala Sai Chaitanya Thunuguntla, Laura Kate Gadanec, Catherine McGrath, Joanne Louise Griggs, Puspha Sinnayah, Vasso Apostolopoulos, Anthony Zulli, Michael L. Mathai |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 43 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |