Pathway Analysis of Allulose as a Sugar Substitute in Mitigating Thrombotic Risks in Sickle Cell Disease Patients
Seong Su Choi, Eun Ji Kim, Su-Kyung Shin, Ji-Yoon Lee, Ji Won Han, Eun-Young Kwon, Heekyong R. Bae · 2024
Read Pathway Analysis of Allulose as a Sugar Substitute in Mitigating Thrombotic Risks in Sickle Cell Disease Patients by Seong Su Choi, Eun Ji Kim, Su-Kyung Shin, Ji-Yoon Lee, Ji Won Han, Eun-Young Kwon, Heekyong R. Bae (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11678832.txt.
Description
Seong Su Choi and co-authors compared two sugar substitutes in mice and in gene data from sickle cell patients, asking which is safer for blood clotting, in a 2024 study. One substitute, erythritol, has been linked to higher clotting risk with long use. A fatty diet is known to make platelets, the clotting cells, stickier. The team fed mice a rich diet with one substitute or the other and traced the gene paths in their platelets.
Erythritol made the diet's clotting effect worse, while allulose softened it. In patient data, the pathways most stirred by sickle cell disease also quieted in the allulose group compared with the erythritol group. Energy parts inside platelets stood out as part of the story. The authors present allulose as a safer sweetener candidate for people prone to clots, pending human trials.
Catalog record
| CREATOR | Seong Su Choi, Eun Ji Kim, Su-Kyung Shin, Ji-Yoon Lee, Ji Won Han, Eun-Young Kwon, Heekyong R. Bae |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 30 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |