Antimicrobial Preservatives in Cyclodextrin-Containing Drug Formulations
Phatsawee Jansook, Hákon Hrafn Sigurdsson, Frédéric Pilotaz, Thorsteinn Loftsson · 2024
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Description
Phatsawee Jansook, Hakon Sigurdsson, Frederic Pilotaz, and Thorsteinn Loftsson reviewed in 2024 how cyclodextrins can weaken the antimicrobial preservatives in drug products. Preservatives keep multidose products free of germs, and cyclodextrins help dissolve drugs that mix poorly with water. The catch is that the two often interact.
Cyclodextrins can bind preservatives into complexes, which can cut or even erase their germ-killing power. Fat-loving preservatives are hit most often, but even water-loving ones can be inactivated. The degree depends on the preservative's structure and traits. In some products, other ingredients with mild antimicrobial action make up the loss. The review explains why some preservatives are more at risk than others.
Catalog record
| CREATOR | Phatsawee Jansook, Hákon Hrafn Sigurdsson, Frédéric Pilotaz, Thorsteinn Loftsson |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 23 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |