Exploring Orodispersible Films Containing the Proteolysis Targeting Chimera ARV-110 in Hot Melt Extrusion and Solvent Casting Using Polyvinyl Alcohol
Valentina Meloni, Laura Halstenberg, Lena Mareczek, Jankin Lu, Bonnie Liang, Nadine Gottschalk, Lena K Mueller, Clara Ràfols, Elisabet Fuguet · 2024
Read Exploring Orodispersible Films Containing the Proteolysis Targeting Chimera ARV-110 in Hot Melt Extrusion and Solvent Casting Using Polyvinyl Alcohol by Valentina Meloni, Laura Halstenberg, Lena Mareczek, Jankin Lu, Bonnie Liang, Nadine Gottschalk, Lena K Mueller, Clara Ràfols, Elisabet Fuguet (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11678735.txt.
Description
Valentina Meloni and eight co-authors formulate a prostate cancer PROTAC drug into films that dissolve on the tongue, in a two thousand twenty-four drug-making paper. ARV-110 belongs to a molecular class beyond the classic rule-of-five, and its poor solubility blocks easy delivery.
Polyvinyl alcohol films were made two ways: hot melt extrusion, screened first by vacuum compression molding, and solvent casting. The drug's heat stability allowed both. Films were tested for disintegration in man-made saliva, drug release under body-like settings, and mechanical strength. All formulations raised solubility with fast disintegration and good stress resistance. The authors lay the groundwork for orodispersible delivery of proteolysis-targeting chimeras in general.
Catalog record
| CREATOR | Valentina Meloni, Laura Halstenberg, Lena Mareczek, Jankin Lu, Bonnie Liang, Nadine Gottschalk, Lena K Mueller, Clara Ràfols, Elisabet Fuguet |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 41 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |