Scientific Validation of Using Active Constituent as Research Focus in Traditional Chinese Medicine: Case Study of Pueraria lobata Intervention in Type 2 Diabetes
Yaping Chen, Qiuqi Wen, Meng Lin, Bing Yang, Liang Feng, Xiaobin Jia, Agnieszka Sliwinska · 2024
Read Scientific Validation of Using Active Constituent as Research Focus in Traditional Chinese Medicine: Case Study of Pueraria lobata Intervention in Type 2 Diabetes by Yaping Chen, Qiuqi Wen, Meng Lin, Bing Yang, Liang Feng, Xiaobin Jia, Agnieszka Sliwinska (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11678734.txt.
Description
Yaping Chen and a team of co-authors test a middle path for studying traditional Chinese medicines: the blend of proven active parts. Their case study appeared in twenty twenty-four. Whole extracts are messy, single compounds ignore teamwork, and kudzu root's use against type two diabetes offered a test bed.
Five active ingredients were fished out by spectrum-effect analysis, network mapping, and docking checks. Combined, the blend beat both the raw extract and any single part at boosting glucose use and glycogen storage in cells. In animals, mid and high doses matched the standard drug metformin at lowering blood sugar. The authors argue the active-constituent focus keeps synergy without the extract's noise.
Catalog record
| CREATOR | Yaping Chen, Qiuqi Wen, Meng Lin, Bing Yang, Liang Feng, Xiaobin Jia, Agnieszka Sliwinska |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 61 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |