Artificial Intelligence-Assisted Comparative Analysis of the Overlapping Molecular Pathophysiology of Alzheimer’s Disease, Amyotrophic Lateral Sclerosis, and Frontotemporal Dementia
Zihan Wei, Meghna R. Iyer, Benjamin Zhao, Jennifer Deng, Cassie S. Mitchell · 2024
Read Artificial Intelligence-Assisted Comparative Analysis of the Overlapping Molecular Pathophysiology of Alzheimer’s Disease, Amyotrophic Lateral Sclerosis, and Frontotemporal Dementia by Zihan Wei, Meghna R. Iyer, Benjamin Zhao, Jennifer Deng, Cassie S. Mitchell (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11678588.txt.
Description
Zihan Wei and co-authors use an AI knowledge graph to compare three brain diseases that waste mind and body. Their twenty twenty-four paper covers Alzheimer disease, amyotrophic lateral sclerosis, and frontotemporal dementia. The graph was built from more than thirty-three million journal papers.
A learning method ranked the proteins and small units most tied to each disease. The frontotemporal set overlapped almost fully with the other two. Shared processes were then mapped with human checks and a language model. Swelling and immune response led the shared list, with synapse work close behind. Readers see where the three diseases truly meet at the molecular level.
Catalog record
| CREATOR | Zihan Wei, Meghna R. Iyer, Benjamin Zhao, Jennifer Deng, Cassie S. Mitchell |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 77 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |