Urtica dioica L. Leaf Extract Dose-Dependently Modulates Oxidative Stress in the Kidney and Exerts Anti-Fibrotic and Anti-Inflammatory Properties by the Molecular Mechanisms Independent of NRF-2 Signalization Mirroring the Effects of Losartan in SHR
Una-Jovana Vajic, Nevena Mihailovic-Stanojevic, Danijela Karanovic, Maja Zivotic, Milan Ivanov, Djurdjica Jovovic, Jelica Grujic-Milanovic, Zoran Miloradovic, Stefanos Roumeliotis · 2024
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Description
Una-Jovana Vajic and co-authors test whether nettle leaf extract can protect the kidneys of rats bred for high blood pressure. Their study appeared in 2024. Earlier work showed the extract lowers blood pressure and fights oxidative stress across the body. Here the team asked whether it guards the kidney itself, and by what route. Rats received water, a standard pressure drug, or one of three extract doses for four weeks.
The standard drug and the middle extract dose both lowered pressure, protein leakage in urine, and signs of stress and scarring in the kidney. The effects matched those of the drug losartan. Notably, the benefit did not run through a master stress switch called NRF-2; some signals tied to that switch even fell. The authors say the extract guards the kidney by a different path.
Catalog record
| CREATOR | Una-Jovana Vajic, Nevena Mihailovic-Stanojevic, Danijela Karanovic, Maja Zivotic, Milan Ivanov, Djurdjica Jovovic, Jelica Grujic-Milanovic, Zoran Miloradovic, Stefanos Roumeliotis |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 44 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |