Assessing Cytotoxicity, Proteolytic Stability, and Selectivity of Antimicrobial Peptides: Implications for Orthopedic Applications
Davide Campoccia, Giulia Bottau, Andrea De Donno, Gloria Bua, Stefano Ravaioli, Eleonora Capponi, Giovanna Sotgiu, Chiara Bellotti, Silvia Costantini, Carla Renata Arciola · 2024
Read Assessing Cytotoxicity, Proteolytic Stability, and Selectivity of Antimicrobial Peptides: Implications for Orthopedic Applications by Davide Campoccia, Giulia Bottau, Andrea De Donno, Gloria Bua, Stefano Ravaioli, Eleonora Capponi, Giovanna Sotgiu, Chiara Bellotti, Silvia Costantini, Carla Renata Arciola (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11678430.txt.
Description
Infections around bone implants are a serious risk in orthopedic surgery, and antibiotic-free materials that kill bacteria are in demand. Davide Campoccia and co-authors assess three antimicrobial peptides, short protein chains named KSL, KSL-W, and Dadapin-1, as candidates for coating implants. They test how toxic the peptides are to human and mouse cells, and how selective they are for bacteria.
In serum-containing fluid, all three peptides showed little to no harm to cells at useful doses. Dadapin-1 was the gentlest on cells, KSL-W held up best over time, and KSL was the most selective for bacteria over human cells. The authors conclude the three peptides show real promise for future anti-infective implant materials.
Catalog record
| CREATOR | Davide Campoccia, Giulia Bottau, Andrea De Donno, Gloria Bua, Stefano Ravaioli, Eleonora Capponi, Giovanna Sotgiu, Chiara Bellotti, Silvia Costantini, Carla Renata Arciola |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 47 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |