Imaging-Based Molecular Interaction Between Src and Lamin A/C Mechanosensitive Proteins in the Nucleus of Laminopathic Cells
Stefania Petrini, Giulia Bagnato, Michela Piccione, Valentina D’Oria, Valentina Apollonio, Marco Cappa, Claudia Castiglioni, Filippo Maria Santorelli, Teresa Rizza, Rosalba Carrozzo, Enrico Silvio Bertini, Barbara Peruzzi, Jaekyung Shim · 2024
Read Imaging-Based Molecular Interaction Between Src and Lamin A/C Mechanosensitive Proteins in the Nucleus of Laminopathic Cells by Stefania Petrini, Giulia Bagnato, Michela Piccione, Valentina D’Oria, Valentina Apollonio, Marco Cappa, Claudia Castiglioni, Filippo Maria Santorelli, Teresa Rizza, Rosalba Carrozzo, Enrico Silvio Bertini, Barbara Peruzzi, Jaekyung Shim (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11678420.txt.
Description
Stefania Petrini and a team of co-authors published a 2024 cell study on two proteins inside the nuclei of cells from patients with laminopathies. These genetic disorders stem from faults in the nuclear lamina, the mesh that lines the nucleus and senses mechanical force. The team focused on lamin A/C and Src, a signaling enzyme known to modify lamina proteins.
Using advanced microscopy, including a super resolution method and lifetime imaging, they compared skin cells from two patients with cells from healthy donors. The two proteins were found together far more in patient cells, and sat closer than in healthy cells. The tight pairing suggests Src joins the altered lamina in driving disease features. Imaging based evidence of this kind can flag new drug targets.
Catalog record
| CREATOR | Stefania Petrini, Giulia Bagnato, Michela Piccione, Valentina D’Oria, Valentina Apollonio, Marco Cappa, Claudia Castiglioni, Filippo Maria Santorelli, Teresa Rizza, Rosalba Carrozzo, Enrico Silvio Bertini, Barbara Peruzzi, Jaekyung Shim |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 34 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |