N-Acetyltyrosine as a Biomarker of Parenteral Nutrition Administration in First-Tier Newborn Screening Assays
C. Austin Pickens, Samyukta Sah, Rahul Chandrappa, Samantha L. Isenberg, Elya R. Courtney, Timothy Lim, Donald H. Chace, Rachel Lee, Carla Cuthbert, Konstantinos Petritis · 2024
Read N-Acetyltyrosine as a Biomarker of Parenteral Nutrition Administration in First-Tier Newborn Screening Assays by C. Austin Pickens, Samyukta Sah, Rahul Chandrappa, Samantha L. Isenberg, Elya R. Courtney, Timothy Lim, Donald H. Chace, Rachel Lee, Carla Cuthbert, Konstantinos Petritis (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11678415.txt.
Description
Austin Pickens and colleagues use a nutrition chemical as a built-in marker in newborn screening. Their assay study from twenty twenty-four addresses false screening burdens. Premature babies on intravenous feeding show raised amino acid levels. Those same levels are screening markers for inherited disorders.
Mislabelled feeding status on blood spot cards creates false alarms. The feeding additive N-acetyltyrosine appears only in fed babies samples. The team built it into first-tier screening assays directly. The marker matched recorded feeding status in residual samples. Mass spectrometry measured it alongside standard screening targets. Labs can now verify feeding status from the sample itself. Fewer false results mean less family anxiety and rework.
Catalog record
| CREATOR | C. Austin Pickens, Samyukta Sah, Rahul Chandrappa, Samantha L. Isenberg, Elya R. Courtney, Timothy Lim, Donald H. Chace, Rachel Lee, Carla Cuthbert, Konstantinos Petritis |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 24 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |