Development of a Population Pharmacokinetic Gabapentin Model Leveraging Therapeutic Drug Monitoring Concentrations
Firas Al-Zubaydi, Andrew Wassef, Leonid Kagan, Luigi Brunetti, Katarina Vučićević, Branislava Miljković · 2024
Read Development of a Population Pharmacokinetic Gabapentin Model Leveraging Therapeutic Drug Monitoring Concentrations by Firas Al-Zubaydi, Andrew Wassef, Leonid Kagan, Luigi Brunetti, Katarina Vučićević, Branislava Miljković (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11678411.txt.
Description
Firas Al-Zubaydi and co-authors build a 2024 model of how a nerve pain drug moves through the body, using blood reads taken in routine care. The drug is cleared by the kidneys and its levels vary a lot from person to person, which makes dose choice hard. Routine drug level checks in hospital hold data that could sharpen that choice.
The team drew records from 82 adults in hospital who had drug levels checked. A simple one-box model fit the data best, with dose-linked uptake and steady clearance. Blood waste levels, a sign of kidney work, were the one trait that clearly shifted clearance. Body weight and diabetes showed no clear effect. The work shows routine care data can feed sound drug models.
Catalog record
| CREATOR | Firas Al-Zubaydi, Andrew Wassef, Leonid Kagan, Luigi Brunetti, Katarina Vučićević, Branislava Miljković |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 30 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |