Cost-Effective Bioimpedance Spectroscopy System for Monitoring Syncytialization In Vitro: Experimental and Numerical Validation of BeWo Cell Fusion
Karim Saadé, Mohammed Areeb Hussain, Shannon A. Bainbridge, Raphael St-Gelais, Fabio Variola, Marianne Fenech · 2024
Read Cost-Effective Bioimpedance Spectroscopy System for Monitoring Syncytialization In Vitro: Experimental and Numerical Validation of BeWo Cell Fusion by Karim Saadé, Mohammed Areeb Hussain, Shannon A. Bainbridge, Raphael St-Gelais, Fabio Variola, Marianne Fenech (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11678286.txt.
Description
Karim Saadé and co-authors build a low-cost device that watches the placenta barrier form in a dish, in a paper from 2024. The placenta guards what passes from mother to fetus, yet drug effects on it are poorly known. Their setup measures electric flow across a layer of placenta-like cells. Shifts in that flow reveal how tight the barrier is.
The cells were grown on a porous sheet and dosed with a drug that makes them fuse, as they do in real tissue. By day four the layer sealed shut, and its electric resistance tripled in treated wells. Computer models then showed why probe placement skews such readings between labs. Values shifted a lot with depth and spacing of the probes. The team urges standard setups so results can be compared. Their cheap system can screen drug effects on the barrier.
Catalog record
| CREATOR | Karim Saadé, Mohammed Areeb Hussain, Shannon A. Bainbridge, Raphael St-Gelais, Fabio Variola, Marianne Fenech |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 30 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |