Natural Gomesin-like Peptides with More Selective Antifungal Activities
Ilia A Bolosov, Ekaterina I Finkina, Ivan V Bogdanov, Victoria N Safronova, Pavel V Panteleev, Tatiana V Ovchinnikova, Alyssa Panitch, Wenbing Dai · 2024
Read Natural Gomesin-like Peptides with More Selective Antifungal Activities by Ilia A Bolosov, Ekaterina I Finkina, Ivan V Bogdanov, Victoria N Safronova, Pavel V Panteleev, Tatiana V Ovchinnikova, Alyssa Panitch, Wenbing Dai (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11678162.txt.
Description
Ilia Bolosov and co-authors search in 2024 for natural variants of a spider peptide that fights microbes, with a focus on fungi. The source peptide comes from a tarantula and acts broadly, most strongly against fungi. The team looked for like peptides in other species, made copies in bacteria, and tested them against bacteria and yeasts plus human cells for harm.
Most new variants were shorter and carried fewer chemical changes than the natural form. One rich variant from another spider matched the natural peptide against fungi but harmed human cells far less. It worked by a like mechanism. The authors present it as a more selective lead for antifungal drug work.
Catalog record
| CREATOR | Ilia A Bolosov, Ekaterina I Finkina, Ivan V Bogdanov, Victoria N Safronova, Pavel V Panteleev, Tatiana V Ovchinnikova, Alyssa Panitch, Wenbing Dai |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 39 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |