In Vitro Dynamic Model Evaluation of Meropenem Alone and in Combination with Avibactam Against Carbapenemase-Producing Klebsiella pneumoniae
Elena N Strukova, Yury A Portnoy, Maria V Golikova, Stephen H Zinner, Antonia Efstathiou, Dimitra K Toubanaki · 2024
Read In Vitro Dynamic Model Evaluation of Meropenem Alone and in Combination with Avibactam Against Carbapenemase-Producing Klebsiella pneumoniae by Elena N Strukova, Yury A Portnoy, Maria V Golikova, Stephen H Zinner, Antonia Efstathiou, Dimitra K Toubanaki (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11678027.txt.
Description
Elena Strukova and co-authors test a drug pairing against pneumonia bacteria that resist last-line antibiotics. Their 2024 study uses a hollow-fiber lab model that mimics drug levels rising and falling in the body. The pairing joins meropenem, a strong antibiotic, with avibactam, a blocker of the enzymes that destroy it.
Meropenem alone failed even against a strain labeled susceptible. Adding the blocker sharpened the drug's power and its measured potency. Results lined up with a simple exposure rule only when lab potency was measured with dense bacterial loads and a dosing-ratio method. The authors say that testing style predicts real effect far better than the standard one.
Catalog record
| CREATOR | Elena N Strukova, Yury A Portnoy, Maria V Golikova, Stephen H Zinner, Antonia Efstathiou, Dimitra K Toubanaki |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 33 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |