Nucleoside Reverse Transcriptase Inhibitor (NRTI)-Induced Neuropathy and Mitochondrial Toxicity: Limitations of the Poly-γ Hypothesis and the Potential Roles of Autophagy and Drug Transport
John Haynes, Arnav Joshi, Ross C Larue, Eric D Eisenmann, Rajgopal Govindarajan, Maria Teresa Cruz · 2024
Read Nucleoside Reverse Transcriptase Inhibitor (NRTI)-Induced Neuropathy and Mitochondrial Toxicity: Limitations of the Poly-γ Hypothesis and the Potential Roles of Autophagy and Drug Transport by John Haynes, Arnav Joshi, Ross C Larue, Eric D Eisenmann, Rajgopal Govindarajan, Maria Teresa Cruz (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11677988.txt.
Description
John Haynes and co-authors review how a class of HIV drugs can damage nerves and cell power plants, in a 2024 paper. The drugs, called NRTIs, anchor modern HIV therapy and work well against the virus. But they can cause a distinct nerve harm marked by tingling pain, prickling, and numbness in the hands and feet.
The standard account blames the drugs for blocking an enzyme that copies mitochondrial DNA, yet the team show gaps in that account. They weigh two other suspects: the cell's self-eating cleanup system, and the pumps and gates that move drugs in and out of cells. Both could shape how much drug reaches the power plants and how the cell copes. Mapping the true path of harm matters, because people with HIV may take these drugs for life.
Catalog record
| CREATOR | John Haynes, Arnav Joshi, Ross C Larue, Eric D Eisenmann, Rajgopal Govindarajan, Maria Teresa Cruz |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 50 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |