Evaluation of the Cancer-Preventive Effect of Resveratrol-Loaded Nanoparticles on the Formation and Growth of In Vitro Lung Tumor Spheroids
Elisa A. Torrico Guzmán, Mitchell Gravely, Samantha A. Meenach · 2024
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Description
Resveratrol, the red-wine compound, fights cancer cells in principle but dissolves poorly in practice, so Elisa Torrico Guzmán and co-authors wrap it in nanoparticles. Their 2024 study loads the compound into a biodegradable sugar-based polymer, making neutral particles about two hundred nanometers wide that release their cargo faster in acid. Lung cancer cells grew in flat layers and in tumor-like balls.
The wrapped compound beat the free compound at slowing cell growth and at preventing the balls from forming and swelling, whether dosed before the balls formed or after. The authors pitch the particles as a preventive treatment candidate for lung cancer.
Catalog record
| CREATOR | Elisa A. Torrico Guzmán, Mitchell Gravely, Samantha A. Meenach |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 34 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |