Integration of Ontogeny-Based Changes for Predicting the Exposure of Diphenhydramine in the Pediatric Population: A PBPK Modeling Approach
Ammara Zamir, Muhammad Fawad Rasool, Faleh Alqahtani, Hussain Alqhtani, Tanveer Ahmad · 2024
Read Integration of Ontogeny-Based Changes for Predicting the Exposure of Diphenhydramine in the Pediatric Population: A PBPK Modeling Approach by Ammara Zamir, Muhammad Fawad Rasool, Faleh Alqahtani, Hussain Alqhtani, Tanveer Ahmad (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11677874.txt.
Description
Ammara Zamir and co-authors build a body model to predict diphenhydramine levels in children in two thousand twenty-four. The drug treats coughs, skin reactions, and severe allergies, and is used off and on in kids. Dosing proof in children is thin, so the team modeled it instead.
Their physiologically based model starts from adult data, young and old, then scales to children by folding in how organs and enzymes mature with age. Built in standard software, it forecasts blood levels over time. Checks against real values kept the key traits, peak level, total exposure, and clearance, within a twofold band. Predicted peaks in children ran about threefold above young adults, a dosing clue.
Catalog record
| CREATOR | Ammara Zamir, Muhammad Fawad Rasool, Faleh Alqahtani, Hussain Alqhtani, Tanveer Ahmad |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 24 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |